New Prostate Cancer Drug Up For Approval ? CBS Washington

(Credit: Joe Raedle/Getty Images)

WASHINGTON (CBSDC/AP) ? Scientists for the Food and Drug Administration say an Amgen drug slowed the spread of cancer to the bone in men with hard-to-treat prostate cancer, though the drug failed to extend life and carried significant side effects.

The Food and Drug Administration will ask a panel of outside experts on Wednesday whether the benefits of Amgen?s Xgeva (ex-jeev?-ah) outweigh its risks, which included bone disease in about 5 percent of patients taking the drug.

Xgeva is already approved for preventing fractures in cancerous bones, and for osteoporosis, in a different formulation called Prolia.

Now the biotechnology company that?s been around since 1980 has asked the FDA to approve its injectable drug for men with recurring prostate cancer that is at high risk of spreading to the bone. Men must have also attempted and failed treatment with hormone therapy.

(TM and Copyright 2012 CBS Radio Inc. and its relevant subsidiaries. CBS RADIO and EYE Logo TM and Copyright 2012 CBS Broadcasting Inc. Used under license. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.)

Source: http://washington.cbslocal.com/2012/02/06/new-prostate-cancer-drug-up-for-approval/

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Too many kids breathe others' smoke in cars: CDC

CHICAGO (AP) ? Texting while driving, speeding and back-seat hanky-panky aren't all that parents need to worry about when their kids are in cars: Add secondhand smoke to the list.

In the first national estimate of its kind, a report from government researchers says more than 1 in 5 high school students and middle schoolers ride in cars while others are smoking.

This kind of secondhand smoke exposure has been linked with breathing problems and allergy symptoms, and more restrictions are needed to prevent it, the report says.

With widespread crackdowns on smoking in public, private places including homes and cars are where people encounter secondhand smoke these days. Anti-smoking advocates have zeroed in on cars because of research showing they're potentially more dangerous than smoke-filled bars and other less confined areas.

The research, from the federal Centers for Disease Control and Prevention, was released online Monday in Pediatrics.

The study is based on national surveys done at public and private high schools and middle schools. Students were asked how often they rode in cars while someone was smoking within the past week. The most common answer was one or two days. The smoker could mean other kids or parents; the study didn't specify.

A CDC fact sheet suggests even small amounts of secondhand smoke can be risky.

"There is no risk-free level of exposure to secondhand smoke," the CDC says.

Overall, 22 percent of teens and pre-teens were exposed to secondhand smoke in cars in 2009, the latest data available. That figure declined gradually during the decade, from 40 percent in 2000, the study found. But still, the numbers of kids still facing the risks "is certainly problematic," said CDC researcher Brian King, the study's lead author.

"The car is the only source of exposure for some of these children, so if you can reduce that exposure, it's definitely advantageous for health," King said.

The CDC advises parents to not allow smoking in their homes and cars, and says opening a car window will not protect kids from cigarette smoke inside.

Measures banning smoking in cars when children are present have been enacted in a handful of states and proposed in several others. The study authors say similar bans should be adopted elsewhere.

___

Online:

American Academy of Pediatrics: http://www.aap.org

CDC: http://1.usa.gov/5aEqiK

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-02-06-Secondhand%20Smoke-Cars/id-a7cdcf0359c64d61a294f9ae544afee1

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For now at least, Romney campaign cruising

Republican presidential candidate former Massachusetts Gov. Mitt Romney greets supporters at his Nevada caucus night victory celebration in Las Vegas, Saturday, Feb. 4, 2012. (AP Photo/Gerald Herbert)

Republican presidential candidate former Massachusetts Gov. Mitt Romney greets supporters at his Nevada caucus night victory celebration in Las Vegas, Saturday, Feb. 4, 2012. (AP Photo/Gerald Herbert)

Tommy Sholeff, 3, holds a sign as he sits on the shoulders of his father Jim Sholeff, at the Nevada caucus night victory celebration for Republican presidential candidate, former Massachusetts Gov. Mitt Romney in Las Vegas, Saturday, Feb. 4, 2012. (AP Photo/Gerald Herbert)

Supporters for Republican presidential candidate, former Massachusetts Gov. Mitt Romney, react to caucus results as they are shown on a television screen during a caucus night watch party, Saturday, Feb. 4, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

El aspirante presidencial republicano y ex gobernador de Massachusetts Mitt Romney saluda a sus simpatizantes en la celebraci?n de su victoria en las asambleas partidarias de Nevada en Las Vegas, el s?bado 4 de febrero de 2012. (AP foto/Julie Jacobson)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney waves to supporters after speaking at a caucus night watch rally, Saturday, Feb. 4, 2012, in Las Vegas. (AP Photo/Julie Jacobson)

LAS VEGAS (AP) ? For now at least, Mitt Romney's presidential campaign seems to mostly be going according to plan. A commanding Nevada victory Saturday night underscored as much.

"You have given me your vote of confidence. And this time, I'm going take it all the way to the White House," an upbeat Romney told a raucous crowd gathered at the Red Rock Resort a few miles from the Las Vegas Strip. He ignored his GOP rivals and instead attacked President Barack Obama, insisting the president doesn't deserve credit for the recent drop in the unemployment rate to 8.3 percent.

"Mr. President, we welcome any good news on the jobs front, but it is thanks to the innovation of the American people in the private sector, and not to you," Romney said in Nevada.

Before the Nevada triumph, the former Massachusetts governor had turned in a strong performance in Iowa and won New Hampshire before suffering a serious setback in South Carolina. He recalibrated and went on to win decisively in Florida. Next up are Colorado, where Romney is expected to perform strongly, and Minnesota, which even advisers acknowledge could emerge as a stumbling block.

Romney still has plenty of challenges as he looks to clinch the nomination.

He's shown a tendency to make comments that provide fodder to his critics, saying recently he was "not concerned" about the very poor. The remark prompted backlash among some Republicans worried he would make similar mistakes while running against Obama. Romney's also still working to prove that he can unite skeptical conservatives behind him ? even though entrance polls in Nevada showed he performed strongly.

And chief rival Newt Gingrich insists he'll stay in the race until summer, and he could win more contests, particularly those in the South.

As Saturday began, Romney campaigned in neighboring Colorado, where he won in 2008 and where advisers say they are confident he can perform strongly again.

"I need your vote on Tuesday!" Romney told the overflow crowd at a Colorado Springs warehouse. Instead of focusing on any of his Republican rivals, he attacked Obama's economic policies.

"He doesn't get credit for things getting better," Romney said there.

As confident as Romney's advisers seem about Colorado, they appear equally as nervous about upcoming Minnesota.

He won the state in 2008, too, and many observers have assumed he could easily win again. But Romney aides say Minnesota is unpredictable for many reasons. It's a small electorate with a strong evangelical contingent ? and the caucus system itself can make the outcomes harder to determine in advance.

In a sign that his team may be considering bypassing the state altogether, Romney on Saturday abruptly canceled plans to headline a rally early Monday in Minneapolis. He decided to head straight to Colorado and leave the Minneapolis event to two of his top surrogates ? former Minnesota Gov. Tim Pawlenty and former Ambassador John Bolton, one of his most conservative backers. Romney doesn't currently plan to visit before Tuesday's voting.

Minnesota's Republican activists are strongly conservative, which could pose problems for Romney as candidates considered more conservative than him ? Gingrich and former Pennsylvania Sen. Rick Santorum ? work to impede the former Massachusetts governor's march to the nomination. Even the libertarian-leaning Ron Paul may end up a player in the Minnesota caucuses.

The political mood in Minnesota has soured of late, with a vitriolic struggle that shut down the state government last year. The sizable evangelical community is concerned about social issues. And a win for one of Romney's competitors could fuel concern that the GOP front-runner still hasn't been able to win over conservatives in his party ? or shake the narrative that he is already the presumptive GOP nominee.

Romney himself has sounded increasingly confident in recent days, calling himself the only candidate in the race who can beat Obama. And when his wife, Ann, introduced him at his Nevada victory speech, she cast the win as one not for February but for November.

"Mitt has started to win in states that are very important for the general election," she said, mentioning wins in New Hampshire and Florida. "This state is going to be an important state in the general. ... We're going to need you again next November."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-02-05-Romney/id-33a96ba4550446e898fabb2894ac0eee

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Nikon 1 future plans revealed: 4K video, brighter lenses, picture effects

Tetsuya Yamamoto, Nikon's head of development was at CES talking up the future plans of the company's 1 system cameras after strong holiday sales. The 10.1 megapixel sensor inside the 1 body is sufficiently capable of shooting 2 and 4K video and bringing that functionality into the unit is planned for a future edition. There's a need for a set of brighter lenses with faster auto-focusing, although we're not sure how much bigger you can get on that petite body. It's also kicking around the option of letting V1 (i.e. more professional) users get at manual AF control and in-camera RAW editing -- while J1 users can expect plenty of features they won't use much, like in-camera effects. It's exciting stuff, but let's hope these new features don't cause the price to climb any higher, eh?

Nikon 1 future plans revealed: 4K video, brighter lenses, picture effects originally appeared on Engadget on Wed, 01 Feb 2012 11:39:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/yrAc3Dzmglo/

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Home Improvement | Actor | Arrested | The Daily Caller

Taran Noah Smith, the actor who played Mark Taylor on the classic ?90s TV series ?Home Improvement,? was arrested early on Wednesday morning under suspicion of driving under the influence.

Los Angeles County police officers pulled Smith over and found a large quantity of marijuana, TMZ reports.

He has has not acted since ?Home Improvement? ended after eight seasons in 1999, according to?IMDB.

Smith, who played the youngest son of Tim Allen?s character, is a regular chip off the old block.

In 1978, Allen was arrested in the Kalamazoo/ Battle Creek Airport for possession of 1.4 pounds of cocaine, and later plead guilty to drug trafficking charges. The convictions could have carried a life sentence, but Allen gave up the names of other drug dealers and served just two and a half years in prison.

Allen was arrested again in 1997 in Birmingham, Mich., for driving under the influence.

WATCH:

Follow Taylor on Twitter

Source: http://dailycaller.com/2012/02/01/tool-time-home-improvement-actor-arrested-for-dui-drug-possession/

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Comodo Programs Manager

Comodo makes a plethora of products ranging from PC tuneup utilities to antivirus suites, but the free Comodo Programs Manager is one for those who wish to manage their systems' applications. The app is designed to let you enable, disable, and update software?as well as rid your computer of broken installations or failed uninstalls that would muddy the registry or hard drive. Comodo Programs Manager has an intuitive, easy-to-use design, but a few niggles keep it from greatness.

Getting Started
Comodo Programs Cleaner scans the hard drive and presents a content summary on the home screen. This home screen consists of a main content area and a dark gray column to the left of it where you'll find four categories: Programs, Drivers and Services, Windows Features, and Windows Updates. In the main content area I saw the number of installed programs (64), drivers and services (423), Windows features and updates (105), and other information. Unfortunately, you can't tweak from this screen, so you have to click one of the categories to the left.

The Comodo Programs Manager Experience
Clicking "Programs" opened a listing of all the applications on my test PC. I could see games (Dead Rising 2), utilities (Geekbench), and a variety of other installs. A drop-down box let me view applications by either their names, icons, or other factors, and a search box returns results on the fly as you key in letters. Clicking an application and then clicking "Standard Uninstall" removes the program from the system. Some programs give you the option to "Change" the install (which opened the installer and let me modify the program to add or remove features) or "Repair" the install (which fixed damaged installations with the click of a button). The application occasionally froze, which required that I close out and then reopen. On the up side, you can back up apps that you install, so that you may recover them at a later time should a problem arise.

"Drivers and Services" lets you remove drivers, but most of the names read as description-less techno-babble, so you should tread lightly in removing them unless you know (or research) what they are first. I understood that an Nvidia driver update was for my PC?s graphics card, but when I saw a very vague ?Beep,? I scratched my head and left it in place. After all, a missing driver can cripple an application. There were a few easily recognizable drivers (such as LogMeIn Remote File System Driver) that I uninstalled with ease.

"Windows Features" lets you disable programs individually, or as a batch. The features are listed in a Windows Explorer-like tree that let me enable/disable the "Games" folder (and all games inside), or dig into the sub-folders and enable/disable the individual titles. I liked the flexibility given here.

"Windows Updates" lets you view all of the installed updates, as well as a list of available updates. The PC test bed had nearly 50 installed updates, and 40 available updates. Acquiring the new updates was as simple as checking the appropriate application boxes and clicking the "Install" button in the lower-right hand corner.

Should You Download Comodo Programs Manager?
Yes. Comodo Programs Manager lets you manage your applications in updates from a central location?no need to tinker within Windows' separate areas. It could be more stable?it froze a bit too frequently for my taste?but it's an app that you should check out if you frequently dabble in application management, and especially if you (like me) install and uninstall apps frequently.

More Utilities Reviews:
??? SocialFolders
??? Comodo Programs Manager
??? TuneUp Utilities 2012
??? SafeSync for Home
??? SafeSync for Business
?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/tY5byFC42eM/0,2817,2399595,00.asp

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IGT Is Betting Online Big-Time (The Motley Fool)

Slot-machine maker International Game Technology (NYSE: IGT - News) looks poised to jump on the bandwagon of companies that are increasing their stake in online gaming. The company plans to acquire Double Down Interactive, one of the biggest virtual casino operators on Facebook.

What's it all about?
Under this deal, IGT will pay $250 million in cash and $85 million in retention payments over the next two years. Additionally, IGT will pay up to $165 million to Double Down, depending on the latter's performance in the next three years.

All in all, this looks like a large amount to pay for a company the size of Double Down, but it's not as if IGT can't afford it. IGT generated over $400 million in free cash flow over the last year.

So is the cash worth it?
This deal will certainly broaden IGT's scope of operations. Already a seller of gaming equipment to casinos, it will now be able to sell virtual products to virtual casinos as well. Being the third-largest social gaming application, Double Down may well provide IGT with a valuable foothold in casino-style social gaming.

Double Down has significantly increased its user count, to 4.7 million now from 3.3 million in October last year, as it capitalizes on the rapidly growing online gaming industry. The industry in itself is expected to grow to $30 billion in 2012 from $20 billion in 2010. What I do like about the deal, however, is the exposure to a new and complementary set of gamers, which is sure to drive IGT's fiscal 2012 earnings. But there's another, larger aspect to it.

What's the catch?
The Double Down deal would mean that IGT is investing around $100 for each one of the former's roughly 5 million users. Now that's a lot of money, something that can be justified only if we consider the potential big bucks IGT can earn if online gambling is legalized. In fact, legalization of online poker would be a dream come true for the casino and gaming industries, something that may be fast becoming a reality as the Justice Department considers doing away with the ban on online gambling.

However, IGT isn't alone. Facebook game maker Zynga (Nasdaq: ZNGA - News) has about 30 million players for its online poker game and could be a great partner for a big branded casino. Industry titan MGM (NYSE: MGM - News) has already partnered with Bwin.Party, and Boyd Gaming and is likely putting pressure on other operators to get a foothold in the space while they still can. IGT could be in for a lot of trouble if an operator inks a deal with Zynga.

Stakes in online gambling will be lower than those at real casinos. Nevertheless, the company's exposure to a widespread online audience should create abundant volumes to push up revenue. Looking at it from that aspect, $500 million doesn't seem particularly extravagant to me, after all.

The Foolish bottom line
This deal could very well be IGT's royal flush. The company seems to be banking on potential revenue based on the expectations that online poker will be legalized. Till then, let's keep our fingers crossed on this one.

Stay tuned for more on this company's fortune. Add International Game Technology to your Watchlist: Click here.

Navjot Kaur does not own shares of any of the companies mentioned in this article. The Motley Fool owns shares of International Game Technology. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/fool/20120130/bs_fool_fool/rx177544

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